Semax 10 mg reconstitution calculator

The FDA’s 2026 review cites reports that semax (free base) “is soluble in water up to 2 mg/mL” (FDA). In a 10 mg vial, 2 mg/mL takes 5 mL of water (10 ÷ 2), or 20 mcg per unit; 5 mL is the example on this page that reaches it. With 2 mL the vial is 5 mg/mL (50 mcg per unit) and with 2.5 mL 4 mg/mL (40 mcg per unit), above that reported figure; 1 mL would make 10 mg/mL, five times it. 5 mL is more than some vials hold, so check yours first (how much water can a vial hold). If the liquid stays cloudy or has particles, don’t use it; ask a pharmacist.

The FDA says “Semax acetate and semax (free base) are different active pharmaceutical ingredients”, and that none of the websites it searched said whether their products contain the base or a salt (FDA). That matters for this vial because the review’s figures differ by form: the 2 mg/mL water solubility is reported for the free base, and the review found no water solubility data for semax acetate. A label that only says “Semax 10 mg” doesn’t tell you which you have, so you can’t tell which figures apply. Ask a pharmacist before mixing.

The FDA’s 2026 review cites reports that “lyophilized semax (free base) is stable for 4 years when stored at -20°C in a tightly closed container” and, once mixed, to “keep solution at +4°C for up to 2-7 days” (FDA). For semax acetate, a nominator’s certificate of analysis gives long-term storage “in a sealed container at 2°C to 8°C”. The review gives the 2-7 days without tying it to how much water is added, so don’t assume more water lengthens it. Whatever the water, the vial holds the same 10 mg, so the same number of doses. The calculator above shows that number for your amount; count it against the window before you add water. More on this: how long reconstituted peptides last.

“Semax is a registered drug in Russia and is available as 0.1% and 1% nasal drops” (FDA). The FDA’s review found “no safety data for semax (free base) and semax acetate administered by the proposed SC ROA” (under the skin) and no human pharmacokinetic studies by any route, and notes “The only ROA discussed in the literature was intranasal.” The FDA’s compounding safety-risk page, in its list of withdrawn nominations, also says compounded semax may pose a risk of immune reactions from aggregation and peptide-related impurities (FDA). So nothing official backs a 10 mg powder vial or the numbers on this page; ask a pharmacist before mixing.