Peptides and GLP-1 medicines
What each compound is, what the research shows and its US regulatory status, with sources for every claim.
34 compounds · Status checked
Prescription medicines
- DulaglutideUS status: FDA-approvedGLP-1 receptor agonist · Trulicity
- LiraglutideUS status: FDA-approvedGLP-1 receptor agonist · Victoza, Saxenda
- OrforglipronUS status: FDA-approvedGLP-1 receptor agonist (non-peptide small molecule) · Foundayo, Orforglipron calcium
- SemaglutideUS status: FDA-approvedGLP-1 receptor agonist · Ozempic, Wegovy, Rybelsus
- SS-31US status: FDA-approvedMitochondrial cardiolipin binder (tetrapeptide) · Elamipretide, Forzinity
- TirzepatideUS status: FDA-approvedGIP and GLP-1 receptor agonist · Mounjaro, Zepbound
FDA-approved medicines. Branded products follow their FDA label.
Approved for one specific use
- PT-141US status: Approved for one useMelanocortin receptor agonist · Bremelanotide, Vyleesi
- TesamorelinUS status: Approved for one useGrowth hormone-releasing factor (GHRF) analog · Egrifta
FDA-approved only for the use on the label. Products sold for anything else are unapproved.
In clinical trials
- CagrilintideUS status: InvestigationalLong-acting amylin analog
- MazdutideUS status: InvestigationalGLP-1 and glucagon receptor dual agonist
- RetatrutideUS status: InvestigationalGIP, GLP-1 and glucagon receptor agonist
- SurvodutideUS status: InvestigationalGlucagon and GLP-1 receptor dual agonist
Still being studied. Not FDA-approved for any use.
Not approved for human use
- AOD-9604US status: Not approvedModified growth hormone fragment
- ARA-290US status: Not approvedPeptide engineered from erythropoietin
- BPC-157US status: Not approvedSynthetic peptide fragment (15 amino acids)
- CJC-1295 / ipamorelinUS status: Not approvedGHRH analog and ghrelin-receptor agonist blend
- DihexaUS status: Not approvedSynthetic angiotensin IV analog
- DSIPUS status: Not approvedSynthetic nonapeptide
- EpitalonUS status: Not approvedSynthetic tetrapeptide
- GHRP-6US status: Not approvedGrowth hormone-releasing peptide (ghrelin-receptor agonist)
- IGF-1 LR3US status: Not approvedInsulin-like growth factor 1 (IGF-1) analog
- KisspeptinUS status: RestrictedReproductive neuropeptide
- KPVUS status: Not approvedTripeptide (fragment of alpha-MSH)
- LL-37US status: Not approvedHuman antimicrobial peptide (cathelicidin)
- Melanotan IIUS status: Not approvedSynthetic melanocortin receptor agonist
- MOTS-cUS status: Not approvedMitochondrial-derived peptide (16 amino acids)
- NAD+US status: RestrictedCoenzyme (not a peptide)
- PinealonUS status: Not approvedSynthetic tripeptide
- SelankUS status: Not approvedSynthetic heptapeptide
- SemaxUS status: Not approvedSynthetic ACTH(4-10) analog
- SermorelinUS status: DiscontinuedGrowth hormone-releasing hormone (GHRH 1-29) analog
- TB-500US status: Not approvedSynthetic thymosin beta-4 fragment (7 amino acids)
- Thymosin alpha-1US status: Not approvedSynthetic thymic peptide, immune modulator
No FDA-approved product is available in the US.
Cosmetic ingredients
Sold mainly in skin and hair products. No drug form is FDA-approved.
How to read these pages
US status, dated and sourced
Every page states the compound’s current FDA status, the date we checked it and the FDA documents behind it. When we’re unsure, we say “not approved for human use in the US”.
Evidence, graded
- Strong human evidence
- Limited human evidence
- Mixed evidence
- Animal or lab studies only
No doses, no sellers
We never suggest doses, protocols or products, and we don’t link to anyone who sells peptides.