Epitalon

Epitalon, also spelled epithalon, is a lab-made peptide of four amino acids: alanine, glutamic acid, aspartic acid and glycine (AEDG). It is not the same as epithalamin: the FDA treats them as different substances, because epithalamin is a mix of peptides extracted from the pineal gland, while epitalon is a single peptide designed from epithalamin’s amino-acid content. It is also different from pinealon, a three-amino-acid peptide (Glu-Asp-Arg) from the same research group.

No. Epitalon is not approved for any use in the US, and the FDA found no approved epitalon product in Canada, Australia, the UK or the European Union. On July 24, 2026 the FDA’s Pharmacy Compounding Advisory Committee reviewed it for insomnia and voted, against FDA staff advice, to recommend adding it to the list of substances pharmacies may compound. That vote is not binding: the FDA would still need to propose and finalize a rule, and as of October 16, 2026 it had not published one.

In lab studies of human cell lines, epitalon increased telomerase activity and telomere length. That has not been shown to translate into health benefits in people. The FDA reads the same finding as a warning sign: longer telomeres are generally linked to higher cancer risk, so it says epitalon “has the potential to be carcinogenic” from a mechanistic standpoint, and the mouse tumor studies are too limited to settle the question.

There is no good evidence that it does. Insomnia was the use the FDA evaluated in 2026. Its review found that the human data describe effects on melatonin or melatonin breakdown products, but no studies in people with insomnia, particularly with injection under the skin, and it concluded there is “a lack of evidence to support the effectiveness” of epitalon for insomnia.

Its safety in people has not been established. The FDA found “no clinical data to support the safety” of epitalon in humans, flagged a possible cancer risk from its effect on telomeres, and noted a risk of immune reactions from aggregation and impurities when injected. FDA searches found no adverse-event reports, which reflects how little it has been studied and monitored, not proof that it is safe. Products sold online are not FDA-approved, so their contents are not verified.

Yes, the calculator is plain arithmetic for any powder vial. There are ready-made pages for a 10 mg vial and a 50 mg vial; enter the amount of water and the dose your prescriber gave you. The FDA’s 2026 review cites reports that epitalon free base has limited water solubility and says it “may not be possible” to make a 3 mg/mL injection with water as the solvent, so ask a pharmacist about any powder that does not fully dissolve. Epitalon is not FDA-approved, and no dose for it has been established.