Selank

Selank is a synthetic peptide of seven amino acids: threonine, lysine, proline, arginine, proline, glycine and proline. It was developed in Russia, where a 2022 review lists it among 14 peptide products registered there, in the “anxiolytic” (anti-anxiety) group. Researchers report anti-anxiety and nootropic (thinking-related) effects, and lab work suggests it may act on GABA receptors, but that mechanism is still a hypothesis.

No. Selank is not approved by the FDA for any use, and it is not in Category 1, 2 or 3 of the FDA’s May 14, 2026 list of substances nominated for pharmacy compounding. Selank acetate was on the FDA’s Category 2 safety-risk list until the nomination was withdrawn. Unlike semax and DSIP, it was not on the agenda of the FDA’s July 2026 compounding advisory committee, and no FDA briefing document exists for it.

The evidence is thin. In a 2008 Russian study of 62 people with generalized anxiety disorder or neurasthenia, 30 took selank and 32 took the benzodiazepine medazepam; the authors reported that the anti-anxiety effects were similar, but “selank had also antiasthenic and psychostimulant effects” (less fatigue, more alertness). A 2014 study of 60 people compared selank with phenazepam, and a 2015 trial gave 30 people phenazepam alone and 40 people selank plus phenazepam, reporting that the combination reduced some side effects of phenazepam. None of these compared selank with a placebo, all are published in Russian, and none is registered on ClinicalTrials.gov.

Both are seven-amino-acid peptides developed in Russia, but they are different molecules with different registered uses there. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is listed as an anxiolytic. [Semax](/compounds/semax) (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of a fragment of the hormone ACTH and is listed as a nootropic. Neither is FDA-approved. The FDA reviewed semax for its July 2026 advisory committee; it has not reviewed selank.

Products sold online come in both forms. A 2020 report from Belgian regulators’ lab found that selank and semax are “freely available either as lyophilized powder for injection purposes or are present in nasal sprays,” after finding them in seized preparations. These products are not approved or tested by the FDA, so what is actually in a vial or spray is not verified.

There is no single correct amount. The water only sets the concentration: mg in the vial ÷ mL of water = mg per mL. For example (numbers for illustration only, not a dose), 10 mg of selank in 1 mL makes 10 mg/mL, so each unit on a U-100 insulin syringe holds 0.1 mg (100 mcg). The same vial in 2 mL makes 5 mg/mL, or 0.05 mg (50 mcg) per unit. More water means each unit holds less; less water means each unit holds more. The reconstitution calculator does this arithmetic for your vial. There is no FDA review or label for selank, so no verified source reports how well it dissolves or how long it keeps once mixed; see how long reconstituted peptides last. Because this product is not FDA-approved, no official label sets a water volume, and the contents of unapproved vials are not verified. Talk to a licensed prescriber or pharmacist before using any unapproved product.